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Psychopharmacology (Berl) 2006;184(2):254256

Purine Biosynthesis: Glutamine donates nitrogen to IMP (inosine monophosphate), a precursor for both purine adenine and guanine synthesis

10.1124/pharmrev.123.001111 Pharmacol

Lowering GSH levels also triggers ferroptosis through deactivation of GPX4, leading to accumulation of lipid peroxides [87] In some cases, GSH depletion alone can induce therapeutic effects without relying on Fenton chemistry, which typically involves HO reacting with Fe 2 to form hydroxyl radicals (OH) that damage critical biomolecules such as DNA, proteins, and lipids