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Mutating H95 affected the ability of Affimer K3 to immunoprecipitate KRAS, with mutation to glutamine (as found in HRAS) reducing the amount of RAS pulled down by 45% and mutation to a hydrophobic leucine residue (as found in NRAS) abolishing RAS immunoprecipitation completely thus giving support to our previous observations (Fig

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In addition to JPH-203, other drugs currently in preclinical and clinical trials targeting LAT1 include IPA-131, QBS-10072S, TLX101-CDx, 124I-ACD-101, 211At-TLX-102, OKY-034, [18F] NKO-028 (Table 1)

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