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In a Swiss study (11), almost half of all general practitioners agreed with prescribing B12 for unexplained fatigue, even though theres not much research to bear it out

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Betaine supplementation lowers plasma homocysteine in healthy men and women

88 A 16-week crossover trial in 36 women did not show any differences between hops (providing 100 mcg of 8-prenylnaringenin per day) and placebo in reducing menopausal symptoms after the first eight-week phase, but women assigned to placebo in the first phase and hops in the second phase had greater symptom relief at week 16 than those assigned to hops followed by placebo, indicating a strong placebo effect and a possible benefit from hops