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(2000) Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF

Additional research is therefore needed to evaluate the optimal daily fluid intake to prevent diseases or improve health, and to issue precise water intake guidelines for adults, but also for other demographic groups, such as children, pregnant and breastfeeding women, senior adults, and residents of hot climates.