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doi: 10.1046/j.1365-2958.2000.02000.x 275 ScarselliM.SerrutoD.MontanariP.CapecchiB.Adu-BobieJ.VeggiD.et al

Loss of GSPT2 disrupts translational fidelity and induces strong antiproliferative effects, particularly in AML (acute myeloid lymphoma) and other sensitive cancer types

Collectively, GGCT functions as a metabolic rheostat that orchestrates mitochondrial homeostasis through diverting Gln flux toward glutathione biosynthesis to fortify redox defense, while enhancing Glc-fueled TCA cycle anaplerosis to sustain cell proliferation