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AND (4) An echocardiogram must be conducted and show valvular lesions of the mitral valve, regurgitation through the mitral valve (MR) on the color Doppler echocardiogram, and have echocardiographic evidence of left atrial and left ventricular dilation (defined as a left atrial-to-aortic root ratio [LA/Ao] equal to or greater than 1.6 and body weight normalized left ventricular internal diameter in diastole [LVIDDN] equal to or greater than 1.7)

60% in the PEG-IFN/RBV arm, as well as higher SVR when treated with mericitabine for 48 weeks (90%) than in those treated for 24 weeks (67%)

doi: 10.3389/fphar.2018.01325 30

H 2 O 2 , a necessary evil for cell signaling