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Treatment with folic acid and / or vitamin C managed to reduce the oxidative stress in the adrenal gland as shown in graph 2-b, 2-c, 2-d and 2-e, the hyperthyroid group showed increased MDA, catalase, and nitric oxide and decreased adrenal reduced glutathione which indicates that there is increased oxidative stress in the adrenal tissue as compared to the control group, by treatment with vitamins the oxidative stress was reduced as compared to the hyperthyroid group

Acknowledgements This project has received funding from the European Unions Horizon 2020 research and innovation programme under the Marie Skodowska-Curie Grant Agreement No

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Two machine learning models were developed: The first model utilized radiomic features from the liver alone, while the second model integrated radiomic features from the liver, spleen, and portal vein