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Recent studies have shown that SIRT1 exerts a neuroprotective effect in MPP+-treated dopaminergic neurons, primarily through deacetylation of PKM2, which improves brain lactate homeostasis and upregulates PGC-1 expression, promoting mitochondrial biogenesis in MPP+-treated cells 8,41

Non-adipocyte fatty acids are mediated primarily through the transmembrane protein CD36, fatty acid transport proteins (FATPs), and fatty acid-binding proteins (FABPs)

Xia L, Tan S, Zhou Y, Lin J, Wang H, Oyang L, et al

To provide further support for the above experimental observations, the isothermal doseresponse CETSA (ITDR CETSA ) was also performed