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Studies comparing localized versus systemic delivery for other biologics (botulinum toxin, platelet-rich plasma) suggest systemic routes produce more uniform results across larger treatment areas

however, it needs to be considered that with the increased number of embryos, the risks of pregnancy increase, so the patient must be fully observed during infertility treatment as well as her pregnancy by a specialist doctor

Long-term oncologic safety remains an open research question because the same migration-promoting and pro-angiogenic activity that supports wound closure has, in some murine melanoma models, correlated with increased metastasis

Its also vital for the production and functioning of blood, cells, and nerves