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33,34 However, with the increasing understanding of redox reactions, multiple lines of experimental evidence show that redox reactions are similar to many other modification modes and can affect molecular signaling pathways through redox modification, thereby affecting various biological activities

Circ Res (2003) 93:102933

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Patients with Mitochondrial Disease: There is an increased risk of valproate-induced acute liver failure and resultant deaths in patients with hereditary neurometabolic syndromes caused by DNA mutations of the mitochondrial DNA Polymerase (POLG) gene (e.g