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Type 1 diabetes, which is characterized by insulin deficiency, results in reduced cardiac glucose uptake and oxidation, as the hearts glucose regulation is primarily insulin dependent

It comes as no surprise that glutathione has been the subject of more than 80,000 papers published in peer-reviewed scientific journals all over the world during the last two decades

This approach was chosen because knockouts and knockdowns of XOR in LLC-PK1 cells were not viable, which was not unexpected given that mouse knockouts of XOR are lethal ( The observed reduction in XO and ALDH2 activity by GTN ( Figure 9 ) appears have an impact on several metabolic pathways, most notably purine metabolism ( Figure 5 )

10.1093/pcp/pcp079 Plant Cell Physiol