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[31] Stiff person syndrome is a neurologic disorder caused by anti-GAD antibodies, leading to a decrease in GABA synthesis and, therefore, impaired motor function such as muscle stiffness and spasm

1982;78(5):43443.PubMed 15

They are best seen using a slit lamp, which is necessary to distinguish them from the more commonly seen flat iris nevi, which are not associated with NF-1