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These ROS are largely derived from non-mitochondrial sources, most notably NOX2, whose activity is frequently driven by oncogenic mutations such as FLT3-internal tandem duplication (FLT3-ITD) [122,123,124]

It is not a free pass continuous, non-pulsatile overstimulation is the theoretical concern behind why the short-acting, pulse-mimicking forms are generally preferred but the it will shut me down like a steroid worry is not how this class of compound works

These CD38KO NK cells are resistant to fratricide, showing superior persistence in immune-deficient mice pretreated with CD38 antibodies and enhancing ADCC activity against CD38 + MM cell lines and primary MM cells

The application of ovarian suppression in breast cancer treatment has been well-studied in clinical trials