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Figure 2 Immediately following a bee sting, the venom delivery system remains embedded in the skin for approximately 30 seconds, allowing for venom release, with at least 90% injected within the first 20 seconds ( 50 ) is 2.8-3.5 mg/kg of body weight ( Typically, the clinical manifestations of bee envenomation can be categorized into local inflammatory reactions, allergic reactions, anaphylactic shock, and systemic toxic reactions ( 3 Bee venom: molecular basis of physiopathology A typical bee sting elicits a local inflammatory response characterized by pain, edema, and erythema

Similarly, dopamine and norepinephrine levels are elevated through exercise-induced activation of the mesolimbic reward pathway, which enhances motivation, focus, and stress resilience [246]