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They contribute to both innate and adaptive immunity in vertebrates

Glycolytic shifts that take place in activated immune cells are not always classically Warburg (increased glycolysis and reduced OXPHOS) as both glycolysis and OXPHOS can be enhanced simultaneously (24)

This cascade leads to a significant increase in TFR1 and Fe 2+ levels, promoting neuronal ferroptosis and lipid peroxidation, which exacerbates muscle atrophy and motor dysfunction in mice