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doi: 10.1097/MPA.0000000000001300 80 JaveedNSagarGDuttaSKSmyrkTCLauJSBhattacharyaSet al

Meneri M, Bonato S, Gagliardi D, Comi GP, Corti S (2022) New insights into cerebral vessel disease landscapes at single-cell resolution: pathogenetic and therapeutic perspectives

NAC supports healthy levels of glutathione by providing the body with cysteine, the rate-limiting factor (a factor that prevents the process from happening more quickly) of glutathione production thus, depleted cysteine can lead to depleted glutathione

Moreover, in this study, the elevated pool of organic acids (TCA intermediates) and vitamins (including ascorbic acid and pantothenic acid) particularly in the stress + FFA treatment, suggests improved energy flux and vitamin cofactor availability, both of which are crucial for enzymatic steps in the ascorbateglutathione cycle [71]