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In this regard, it has been reviewed recently that systemic administration of the DHP isradipine suppresses cytosolic calcium transients, increases mitochondrial mass and lowers mitophagy in dopaminergic neurons 54

Dogs with IMHA are predisposed to thrombosis, particularly in pulmonary arteries (Carr et al 2002, DeLaforcade et al 2019), and hypoxic injury to tissues may contribute to hyperlactatemia and organ injury evident in many patients (MacNeill et al 2019)