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Mouse models In this work, we used and Munc13-4-deficient ( Jinx ) mice 56 and inbred control wild-type mice, as well as C57BL/6J from The Scripps Research Institute colony

In addition, recent studies have indicated that inhibiting or alleviating inflammation by reducing macrophages and inhibiting inflammatory factors can reduce the cyst burden and improve kidney function

These organ systems exemplify how immune cell mitochondrial dysfunction can influence surgical recovery and how interventions targeting these pathways have fared clinically ( Figure 7 )