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Clin Nutr 38(2):485521

Science 304 : 843846

doi: 10.1146/annurev.physiol.70.120806.095256 14

While the molecular mechanisms of APAP hepatotoxicity are diverse and include different players, including innate immune response, in this review we will focus on the mitochondriallysosomal axis, which has emerged as a novel liason in several pathologies, including lysosomal storage diseases (Torres et al., 2017a), to pinpoint its role in APAP-mediated hepatotoxicity