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Jan 7 2023;doi:10.1007/s11325-022-02770-4

We hypothesized whether GabT may convert also the C5-homolog 5-aminovalerate (AVA) to glutarate semialdehyde and whether GabD converts the glutarate semialdehyde to GA (Fig

Moreover, the acceleration of the glycolysis in cancer cells can relieve the inhibition of granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) in myeloid-derived suppressor cells (MDSCs) through AMPK-ULK1 and autophagy pathways, and the infiltration of MDSCs promotes tumor growth and metastasis and reduces the immune activity of T cells [364]