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Dracorhodin, the principal bioactive flavonoid of SD, has been experimentally or clinically documented for diabetic foot ulcers, pressure sores and surgical wounds, upper-gastrointestinal bleeding and hemorrhoids, as well as UVB-induced skin damage and various tumours 14,15,16

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Supplemental short-acting opioids may be used as methadone levels accumulate, especially for patients previously utilizing fentanyl (e.g., oxycodone 10-20 mg titrated to effect)