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39 (7), e70518

In humans, prolonged exposure to chronic stressors, whether social, environmental, or occupational, may lead to comparable atrophy, contributing to the impaired emotion regulation and decision-making commonly observed in depression (97)

Hypoxia-inducible factor-1 (HIF-1) can act upstream of AMPK in settings of hypoxia and inflammatory stress, where NF-B/MAPK nodes are concurrently engaged [193,194]