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They have the functions of phagocytosing pathogenic bacteria and toxic particles, secreting cytokines, and chemotaxis ( 2.5 ) stimulated the high expression of IL-4 in mouse BALF, which a key inducer of M2 polarization, acting on the IL-4R on the surface of AM cells, inducing downstream STAT6 phosphorylation and nuclear translocation, binding to the Matrix Metalloproteinase -12 (MMP12) promoter region and promoting the expression of MMP12, causing excessive degradation of extracellular matrix (ECM), which is related to the destruction of lung tissue in COPD ( 2.5 , PM 2.5 reduced NAD + /SIRT1 activity to increase the activity of histone acetyltransferases, resulting in elevated expression of pro-inflammatory genes in AM ( CD8 + T cells are an important subgroup of T cells and are associated with tissue damage and the expansion of inflammatory responses

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Pericyte loss represents one of the earliest events in DR that occurs as a direct result of metabolic dysregulation in the retinal neurovasculature (9)