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Chronic activation of JNK JAK/STAT and oxidative stress signaling causes the loser cell status

Minimal Residual Disease (MRD) in chronic lymphocytic leukemia (CLL) detected by fluorescent in situ hybridization (FISH) on FACS-sorted cells

Advances in liquid detection technologies now enable detection and longitudinal monitoring of circulating tumor cell-derived cell-free DNA in cerebrospinal fluid or peripheral blood, offering actionable insights for clinical decision-making or prognostic prediction in patients with tumors [23]

To understand whether the transition represented overall folding of the RNA or local interactions in the ligand-binding site, we measured the melting temperature ( T m ) by circular dichroism (CD) spectroscopy