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Environ Mutagen, 7(Suppl 3): 28

cerevisiae , it was proposed that all nascent FeS clusters were synthesized in the mitochondrial matrix, and a sulfur component was exported to cytosol by the ABC transporter, Atm1 (homologous to ABCB7 in mammals), whereupon specialized proteins in the cytosol, named the cytosolic iron sulfur assembly machinery or CIA machinery completed synthesis and delivery of FeS cofactors to numerous cytosolic and nuclear proteins (Lill et al