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Beyond catalysis, the GCH1-GFRP complex regulates BH4 synthesis for use by PAH and eNOS, while the lysosomal Sestrin2-Rag complex senses amino acid levels to modulate mTORC1 signaling

943 NG/EDA is triggered by the acidic and edaravone-induced high levels of GSH microenvironment, enabling selective and sustained release of edaravone at the site of ischemic injury to enhance its neuroprotective effects