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The development of rheumatoid arthritis is based on a genetic predisposition, such as the HLA-DR4 alleles, that create antibodies against citrullinated proteins, and on environmental triggers such as infection or smoking [8]

(1999) Met-induced JNK activation is mediated by the adapter protein Crk and correlates with the Gab1 - Crk signaling complex formation

Stockwell et al., 2020), synthesizes antioxidant GSH by up-taking cystine and exchanging intracellular glutamate at a molar ratio of 1:1 and then reducing cystine to cysteine (Seibt et al., 2019