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Once water-soluble, these neutralized toxins can be safely and efficiently excreted from the body through bile and urine

As shown in Supplementary Figure 2, liver cells in the NH group were well-preserved and orderly arranged

Therefore, a combination of multiple strategies such as HFD+fructose and CD+HFD is widely employed to induce insulin resistance, dyslipidemia, ER stress, fibrosis and NASH (111)

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Pablo Rivera-Fuentes reports financial support was provided by Swiss National Science Foundation.