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Molecular mechanisms of supramolecular selfassembly in TCM Similar to other supramolecular compounds, supramolecular systems in TCM depend on diverse noncovalent interactions to drive spontaneous molecular assembly and are modulated by external environmental factors such as pH, temperature, and ionic strength [22, 23]

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Manipulation with ezrin expression in astrocytes also indicated the resilience of mice to chronic stress: ezrin downregulation increased susceptibility to stress and facilitated emergence of depression-like behaviors, whereas overexpression of ezrin made mice resistant to chronic stress 147

Antioxidants 7(8):102 Kotla NK, Dutta P, Parimi S, Das NK (2022) The role of ferritin in health and disease: recent advances and understandings