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Chronic alcohol ingestion increases the ratio of attenuated NAD/oxidized NAD (NADH/NAD+) in hepatocytes, disrupting the mitochondrial beta-oxidation of fatty acids and leading to liver steatosis (Masia et al., 2018)

On the other hand GABA inhibits the secretion of TRH (Wiens & Trudeau, 2006) CFS patients have experienced relief from desmopressin (Miwa, 2017) and CRH (Pereira et al., 2021)

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AUTHORS CONTRIBUTIONS All authors contributed greatly to the success of this work CONFLICT OF INTEREST No conflict of interest to declare in this manuscript ACKNOWLEDGEMENT This case was carried out without direct funding, and the authors would like to thank the Head and the entire staffs of the Department of Human Physiology, College of Medical Sciences, Ahmadu Bello University, Zaria, for their support and provision of necessary facilities