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While gastrointestinal AEs such as nausea and vomiting dominate safety reports 8 and recent pharmacovigilance studies highlight increasingly recognized risks including acute pancreatitis, nephritis, hypotension, and syncope 9,10,11 , emerging data suggest that GLP-1 RAs may be associated with neurological adverse events (NAEs) 12,13

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In obese mice, 14 days of AOD-9604 treatment reduced body weight gain by over 50% compared to controls

Additionally, the antibody was improved with a silenced IgG4 Fc, which does not deplete or interfere with the normal effectors (80)