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Oxidant stress, mitochondria and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity

Plant Biol

MLL4 PHD23 (aa 227-324) was produced as described in ref

Under conditions of oxidative stress, excess H 2 O 2 and O 2 can increase the phosphorylation levels of RIPK1 and RIPK3, activating MLKL and inducing membrane rupture [237]