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Biomed Chromatogr 2009;23:658-64

Animal studies suggest that reducing NNMT activity may: increase cellular energy expenditure improve metabolic efficiency reduce fat accumulation influence NAD metabolism These findings have made NNMT a potential therapeutic target for metabolic disease research

This is because the absence of aralar does not exclude mitochondrial glutamate synthesis, especially if a substantial amount of -ketoglutarate is supplied from non-glucose source in these young animals