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Besides DPN, in which the pathways leading to increased oxidative stress are well-described, oxidative stress also plays a prominent role in PN of etiologies other than diabetes mellitus, e.g., in chemotherapy-induced PN (CIPN) and alcohol-induced PN (AIPN)

Handling and Storage Recommendations Store unopened vials at 28 C , with 20 C recommended for long-term storage Protect from light and moisture After reconstitution, store solutions at 28 C and use within laboratory-defined timeframes Avoid repeated freeze-thaw cycles Follow standard laboratory safety, labeling, and handling procedures All handling is performed within laboratory research environments