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Rabenstein, T

WZ: Writing review & editing, Formal analysis

This approach has demonstrated effectiveness in reversing age-related decline in animal models.58 Suppression of Senescence-Associated Secretory Phenotype (SASP): Senescent cells secrete pro-inflammatory cytokines (IL-6, IL-8, TNF-), growth factors, chemokines, and matrix metalloproteinases, which create a pro-inflammatory environment that accelerates aging and disease progression.59 For example, dasatinib and quercetin is a combination therapy that reduces SASP production and enhances the clearance of senescent cells.60 Similarly, fisetin and curcumin are flavonoids with senolytic properties that inhibits SASP secretion, reduce inflammation and improve tissue function.61,62 Targeting Heat Shock Proteins (HSPs): Heat shock proteins (HSP90, HSP70) are molecular chaperones that stabilize key proteins involved in senescence.63 HSP90 inhibitors (eg, 17-AAG, Geldanamycin) cause degradation of senescence-associated proteins, leading to senescent cell death

At M12, a significant decrease of fat mass and a significant increase in skeletal muscle mass were found in Group-A2 as compared to M0, otherwise no significant changes were found in other parameters