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Site- and condition-specific imputation was performed using the scImpute function in PhosR (88) if the protein was quantified in more than 50% of samples from the same drug treatment

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The once-weekly subcutaneous injection format mirrors the administration route of other GLP-1-based therapies already familiar to clinicians and patients, such as semaglutide (Wegovy/Ozempic) and tirzepatide (Mounjaro)