1 Introduction Acute respiratory distress syndrome (ARDS) is a severe, life-threatening inflammatory condition of the lungs commonly triggered by infections such as bacterial pneumonia, viral pathogens (e.g., influenza and SARS-CoV-2), and systemic sepsis ( The pathogenesis of ARDS involves an exaggerated immune response that damages alveolar structures, disrupts the alveolar-capillary barrier, and promotes excessive inflammation, vascular leakage, and oxygenation failure ( Regulated cell death pathways, such as apoptosis, pyroptosis, necroptosis, and ferroptosis, play pivotal roles in controlling inflammation and maintaining tissue integrity
In: Alvarez-Suarez JM (ed) Bee productschemical and biological properties
These results demonstrate that the GD and CTD of AAGAB must be physically connected to regulate AP2 assembly, further supporting our conclusion that AAGAB is a bona fide bi-handed assembly chaperone relying on the proximity effect to regulate substrate pairing
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