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Both pathways rely on CD73 to convert AMP into the final product, namely adenosine ( + ( 2+ channel of endolysosomes to releases Ca 2+ , and Ca 2+ acts as the second messenger to promote angiogenesis, thus promoting tumor growth and metastasis ( 2+ by VEGFR2/NAADP/TPC2/Ca 2+ signaling pathway, which also leads to angiogenesis ( Figure 4 )

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In recent years, nanodrugs based on TP have been developed for RA therapy, including folate-modified TP liposomes, TP nanoemulsion gel, and TP-carrying dendritic cell-derived exosomes, which are promising for localized treatment with reduced toxicity (111113)

Visual inspection is the most practical viability test