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It has been verified that ferroptosis is involved in the pathophysiological process of SCI, mainly manifested as ROS increased, iron overload, glutamate, and lipid peroxidation accumulation related to ferroptosis in SCI ( Figure 4 ) (90)

Rather, any apparent cellular selectivity is likely determined jointly by factors such as target protein expression, E3 ligase distribution, tumor microenvironment (TME) features, and delivery strategy

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