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Leber hereditary optic neuropathy LHON is the most prevalent mitochondrial disease, characterized by maternal inheritance and a pronounced male sex bias

Improving sleep quality leads to better mental health: A meta-analysis of randomised controlled trials

359,360 In the diabetic state, abnormalities in cellular energy metabolism affect macrovascular and microvascular lesions, 361,362,363 including abnormalities in substrate delivery to vascular EC or target organ cells (e.g., cardiac myocytes, thylakoid cells in glomeruli, and neurons and Schwann cells in peripheral nerves), conversion of the ratio of cell-specific fuel sources between glucose intermediates, fatty acids, and amino acids, changes in respiratory chain protein function, and uncoupling of respiratory chains

While this might not establish an ergothioneine causeand-effect relationship (e.g., lower ergothioneine levels could be a consequence of brain cell loss), it underscores the potential significance of this compound