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However, overexpression of Pfkfb3 activates glycolysis in neurons through the APC/C-Cdh1 pathway, which inhibits the pentose phosphate pathway (PPP), reduces the oxidation of glucose-6-phosphate (G6P), decreases the production of reduced glutathione, and finally leads to oxidative stress and apoptosis (Herrero-Mendez et al., 2009)