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Abbreviations 2M: Beta-2-microglobulin CAPP: Concerted Action Polyp Prevention CEA: Carcinoembryonic antigen CI: Confidence interval CRC: Colorectal cancer CTLA-4: Cytotoxic T-lymphocyte antigen 4 dMMR: Mismatch repair deficient EMT: Epithelialmesenchymal transition FDA: US Food and Drug Administration FSP: Frameshift peptide HDAC: Histone deacetylase HNPCC: Hereditary non-polyposis colon cancer HPV: Human papillomavirus ICI: Immune checkpoint inhibitor KIR2DL1: Killer cell immunoglobulin-like receptor 2DL1 LS: Lynch syndrome LS-CRCs: Lynch syndromeassociated colorectal cancers MAb: Monoclonal antibody MLH1: mutL homolog 1 MSH2: mutS homolog 2 MSH6: mutS homolog 6 MMR: Mismatch repair MSI: Microsatellite instability MSS: Microsatellite stability MUC1: Mucin 1 NK: Natural killer NSAID: Nonsteroidal anti-inflammatory drug OS: Overall survival PD-L1: Programmed death-ligand 1 PFS: Progression-free survival PMS2: Post-meiotic segregation increased 2 TIL: Tumor-infiltrating lymphocyte TME: Tumor microenvironment Treg: Regulatory T cell References Papers of particular interest, published recently, have been highlighted as: Of major importance Le DT, Kim TW, Van Cutsem E, Geva R, Jager D, Hara H, et al

Serious adverse effects in the infant are unlikely unless the mother has toxic serum theophylline concentrations

EDTA prevents any aggregation