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Hence, dilatation of the small intrahepatic bile ducts with no or minimal dilatation of the large bile ducts is an important characteristic for diagnosis by the aforementioned imaging techniques, thus presenting as too many intrahepatic ducts sign in MR (245, 249)

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A major challenge in neurodegeneration research is to elucidate how the reactive astrocytes are regulated and how these phenotypic shifts contribute to disease progression