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Therefore, targeting iron metabolism disorders, lipid peroxidation accumulation, and osteoblast ferroptosis in subchondral bone may provide new therapeutic strategies for OA

For each gene, a gene effect and score (likely maximum effect size and score) and P values were calculated using the casTLE statistical framework as previously described 32,33

[Google Scholar] A secreted catalase contributes to Puccinia striiformis resistance to host-derived oxidative stress

There is also increasing evidence that deregulation of GSH synthesis contributes to the pathogenesis of diseases such as diabetes mellitus, pulmonary and hepatic fibrosis, alcoholic liver disease, cholestatic liver injury, endotoxemia, and drug-resistant tumors cells [10]