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In disease contexts, CHAC2 is often found at reduced levels in some cancers, such as gastric and colorectal cancers, where it acts as a tumor suppressor by promoting apoptosis and autophagy through ER stress pathways

After transfection and two rounds of baculovirus amplification, 20 mL (cyclin L2-SAP30BP) or 40 mL (CDK11B) of insect cell culture supernatant was used to infect 1-L (cyclin L2-SAP30BP) or 2-L (CDK11B) cultures of High5 insect cells (Thermo Fisher Scientific)

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Perrone P, Moriello C, Alessio N, Manna C, DAngelo S (2025) Cytoprotective potential of Annurca apple polyphenols on mercury-induced oxidative stress in human erythrocytes