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1 Introduction Idiopathic pulmonary fibrosis (IPF) is the most common form of idiopathic interstitial pneumonia, characterized by chronic progressive pulmonary fibrosis associated with a steady worsening lung function, ultimately leading to respiratory failure and death ( IPF is characterized by tissue remodeling, fibroblast proliferation, and extracellular matrix (ECM) accumulation which involves the interstitial, distal airway, and alveolar parenchyma ( Macrophages are considered an integral component of innate immunity that plays an essential role in immune function, tissue remodeling, and inflammatory response

Rapid urbanization, poor dietary choices, lack of physical activity, and increased consumption of tobacco and alcohol have led to an epidemic of cardiovascular disease (CVD) in these countries

is supported by the Medical Research Service of the Veterans Affairs Department and University of Miami Miller School of Medicine

Similarly, Man et al