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Quercetin, a natural flavonoid, significantly inhibited nickel-induced inflammation in mouse liver by decreasing Nrf2 DNA methylation and inhibiting the p38 MAPK signaling pathway (Zhao L

This Notch intracellular domain then translocates to the nucleus, where it forms a complex with CSL and Mastermind-like, regulating target gene expression and influencing critical cellular processes such as inflammation, apoptosis, and proliferation, which are crucial to the pathogenesis of PH as demonstrated by several clinical and preclinical studies (Fig

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