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Deeper understanding of the biological activity of coumarin and its derivatives, along with methods to improve their bioavailability, may lay a stronger foundation for their future therapeutic applications

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Pharmacology 13 , 274279 (2017)

Similar tunnels have been found in all thiamine pyrophosphate-dependent enzymes with known crystal structures, whether dimeric or tetrameric, such as transketolase, an enzyme of the pentose phosphate pathway