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Akbari, M., Sogutdelen, E., Juriasingani, S

While the precise contribution of each pathway and the specific post-translational modifications on FOXO1 were beyond the scope of this study, it is plausible that KRAS-driven alterations in PI3K/AKT/mTOR, ERK and PKA signalling not only modulate FOXO1 functional state but also drive its mRNA levels through FOXO1 transcriptional autoregulation (Shen et al, 2014)

In the development of new therapies, metabolomics has identified numerous therapeutic targets for aberrant metabolic pathways by systematically comparing the metabolic differences between cancer and surrounding tissues

Levels naturally decline with age, stress, alcohol, and intense training