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Thus, the complex and cell-specific roles of HIF render it difficult to predict the net effect of HIF-PHIs in vivo , and detailed research should be carried out under each condition

Similarly, the niche in FD appears to create a similar challenge for conventional depleting therapies

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g-j , Ferroptosis-sensitive cell lines HT-1080 (g) and NCIH522 (h) , and ferroptosis-resistant cell lines HCT116 (i) and SKMEL28 (j) were grown in control (208 M cystine